4-Amino-2,6-dichlorophenol → 6-(cyclohexylamino)-N-(3,5-dichloro-4-hydroxyphenyl)pyrimidine-4-carboxamide
反応式
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:23]=[C:22]([Cl:24])[C:21]([OH:25])=[C:20]([Cl:26])[CH:19]=1>>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([OH:25])=[C:20]([Cl:26])[CH:19]=3)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
3
実験手順
Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-2,6-dichlorophenol (ABCR), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
出典と根拠
- ORDレコード
- ord-70250ac2943c4a5f96e28d0342a397f3
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399448B2
反応ノート
読み込み中…