HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2,6-dichlorophenol → 6-(cyclohexylamino)-N-(3,5-dichloro-4-hydroxyphenyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2,6-dichlorophenol | HCID 80037 | — |
| Reactant | 6-(Cyclohexylamino)pyrimidine-4-carboxylic acid | HCID 59447075 | — |
| Product | 6-(cyclohexylamino)-N-(3,5-dichloro-4-hydroxyphenyl)pyrimidine-4-carboxamide | HCID 25182749 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-2,6-dichlorophenol (ABCR), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-70250ac2943c4a5f96e28d0342a397f3 |
| Source note | uspto-grants-2013_03 |