4-Aminophenethyl alcohol → 6-(cyclohexylamino)-N-(4-(2-hydroxyethyl)phenyl)pyrimidine-4-carboxamide

HRID 1946750Notes

Reaction equation

HRID 1946750 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][OH:26])=[CH:20][CH:19]=1>C(#N)C>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][OH:26])=[CH:20][CH:19]=3)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 251827806-(cyclohexylamino)-N-(4-(2-hydroxyethyl)phenyl)pyrimidine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 2-(4-aminophenyl)ethanol (Fluka), the title compound was obtained as a white solid after trituration in acetonitrile.

Sources & evidence

ORD record
ord-2c36ee658523465e8b2ed1be4fb5064a
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Reaction notes

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