Hydrochloric Acid → HCID 68153415, compound

HRID 1946927Notes

Reaction equation

HRID 1946927 reaction equation
C(O)=O.C(OC([N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:20])[CH:18]=2)[CH:13]=[C:12]1[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2([CH3:34])[N:32]=[C:31]([NH2:33])[CH2:30][O:29][CH2:28]2)[CH:22]=1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:20].[Cl:20][C:17]1[CH:18]=[C:19]2[C:14]([CH:13]=[C:12]([C:21]3[CH:22]=[C:23]([C:27]4([CH3:34])[CH2:28][O:29][CH2:30][C:31]([NH2:33])=[N:32]4)[CH:24]=[CH:25][CH:26]=3)[NH:11]2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68153477HCID 68153477, compound

Product 1

HCID 68153415HCID 68153415, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2-[3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-6-chloro-indole-1-carboxylic acid tert-butyl ester formate (12 mg, 0.02 mmol) and hydrochloric acid in dioxane (4M) was left at room temperature for 7 hours. For the workup, the solution was evaporated at reduced pressure and the residue dried at high vacuum to yield the (RS)-5-[3-(6-chloro-1H-indol-2-yl)-phenyl]-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine hydrochloride as an amorphous brown material. MS (ISP): m/z=340.1 [M+H]+.

Workup

  1. customFor the workup, the solution was evaporated at reduced pressure
  2. customthe residue dried at high vacuum

Sources & evidence

ORD record
ord-e5232d15a4734eeaa812cfdb8880f695
Source dataset
uspto-grants-2013_03
Patent number
US08399459B2

Reaction notes

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