反应详情

In a manner analogous to that described for the preparation of Example 1, the palladium-catalyzed coupling of (RS)-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester (intermediate XIII-1) with 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinonitrile using [1,1′-bis(diphenylphosphino)ferrocene]dichloro-palladium(II) as the catalyst yielded the title compounds as a white semisolid. MS (ISP): m/z=393.2 [M+H]+.

1. customIn a manner analogous to that described for the preparation of Example 1