HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile → HCID 68153473, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile | HCID 16414216 | — |
| Reactant | HCID 66666279 | HCID 66666279 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 68153473 | HCID 68153473 | — |
Reaction Steps
In a manner analogous to that described for the preparation of Example 1, the palladium-catalyzed coupling of (RS)-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester (intermediate XIII-1) with 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinonitrile using [1,1′-bis(diphenylphosphino)ferrocene]dichloro-palladium(II) as the catalyst yielded the title compounds as a white semisolid. MS (ISP): m/z=393.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399459B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-78da7533fb0943d98c802c7ac8c59698 |
| Source note | uspto-grants-2013_03 |