Lawesson's reagent → HCID 86668503, compound

HRID 1946937Notes

Reaction equation

HRID 1946937 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:16]4([CH3:23])[NH:21][C:20](=O)[CH2:19][O:18][CH2:17]4)[CH:13]=[CH:14][CH:15]=3)[NH:7][C:6]=2[CH:24]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:16]4([CH3:23])[NH:21][C:20](=[S:34])[CH2:19][O:18][CH2:17]4)[CH:13]=[CH:14][CH:15]=3)[NH:7][C:6]=2[CH:24]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 68153467HCID 68153467, compound

Product 1

HCID 86668503HCID 86668503, compoundYield 98%

Procedure

In close analogy to the procedure described for the preparation of Intermediate XVIII-1, the reaction of 5-[3-(6-chloro-1H-benzoimidazol-2-yl)-phenyl]-5-methyl-morpholin-3-one (202 mg, 0.6 mmol) with Lawesson's reagent yielded the title compound (210 mg, 98% of theory).

Workup

  1. customIn close analogy to the procedure described for the preparation of Intermediate XVIII-1

Sources & evidence

ORD record
ord-5189c7acd8bd4355af1c9956b6eef279
Source dataset
uspto-grants-2013_03
Patent number
US08399459B2

Reaction notes

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