Lawesson's reagent → HCID 86668504, compound

HRID 1946939Notes

Reaction equation

HRID 1946939 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:11]=[C:12]([C:16]4([CH3:23])[NH:21][C:20](=O)[CH2:19][O:18][CH2:17]4)[CH:13]=[CH:14][CH:15]=3)=[N:7][C:6]=2[CH:24]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:11]=[C:12]([C:16]4([CH3:23])[NH:21][C:20](=[S:34])[CH2:19][O:18][CH2:17]4)[CH:13]=[CH:14][CH:15]=3)=[N:7][C:6]=2[CH:24]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 68153442HCID 68153442, compound

Product 1

HCID 86668504HCID 86668504, compoundYield 57%

Procedure

In close analogy to the procedure described for the preparation of Intermediate XVIII-1, the reaction of (RS)-5-[3-(5-chloro-benzooxazol-2-yl)-phenyl]-5-methyl-morpholin-3-one with Lawesson's reagent yielded the title compound (57% of theory). MS (ISP): m/z=359.1 [M+H]+.

Workup

  1. customIn close analogy to the procedure described for the preparation of Intermediate XVIII-1

Sources & evidence

ORD record
ord-b052a0404b1b436d936db0f03bc2d8ed
Source dataset
uspto-grants-2013_03
Patent number
US08399459B2

Reaction notes

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