HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 178486846, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178486880 | HCID 178486880 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178486846 | HCID 178486846 | — |
Reaction Steps
800 mg of 3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline, 7 ml of thionyl chloride and 0.1 ml dimethylformamide are refluxed for 3 hours. The volatile components of the reaction mixture are eliminated using the rotary evaporator, the residue is combined with toluene and concentrated again by rotary evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399461B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b71542fb8184459fa69ecc2e9b84af89 |
| Source note | uspto-grants-2013_03 |