Thionyl Chloride → HCID 178486846, compound

HRID 1946941Notes

Reaction equation

HRID 1946941 reaction equation
O=[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:29][CH3:30])=[C:9]([O:12][C@H:13]3[CH2:18][CH2:17][C@@H:16]([N:19]([C:21]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[O:22])[CH3:20])[CH2:15][CH2:14]3)[CH:10]=2)[N:5]=[CH:4][NH:3]1.S(Cl)([Cl:33])=O>CN(C)C=O>[ClH:33].[Cl:33][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:29][CH3:30])=[C:9]([O:12][C@H:13]3[CH2:18][CH2:17][C@@H:16]([N:19]([C:21]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[O:22])[CH3:20])[CH2:15][CH2:14]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178486880HCID 178486880, compound

Product 1

HCID 178486846HCID 178486846, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

800 mg of 3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline, 7 ml of thionyl chloride and 0.1 ml dimethylformamide are refluxed for 3 hours. The volatile components of the reaction mixture are eliminated using the rotary evaporator, the residue is combined with toluene and concentrated again by rotary evaporation.

Workup

  1. customthe rotary evaporator
  2. concentrationconcentrated again by rotary evaporation

Sources & evidence

ORD record
ord-b71542fb8184459fa69ecc2e9b84af89
Source dataset
uspto-grants-2013_03
Patent number
US08399461B2

Reaction notes

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