Hydrochloric Acid → HCID 178484835, compound

HRID 1946942Notes

Reaction equation

HRID 1946942 reaction equation
[CH2:1]([N:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][C:13]([O:35][CH3:36])=[C:14]([O:19][C@H:20]3[CH2:25][CH2:24][C@@H:23]([N:26](C(OC(C)(C)C)=O)[CH3:27])[CH2:22][CH2:21]3)[CH:15]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:37]>C(O)C>[ClH:37].[CH2:1]([N:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][C:13]([O:35][CH3:36])=[C:14]([O:19][C@H:20]3[CH2:21][CH2:22][C@@H:23]([NH:26][CH3:27])[CH2:24][CH2:25]3)[CH:15]=2)[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486843HCID 178486843, compound

Product 1

HCID 178484835HCID 178484835, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared by treating 3-benzyl-3,4-dihydro-4-oxo-6-{cis-4-[N-(tert-butyloxycarbonyl)-N-methyl-amino]-cyclohexyl-oxy}-7-methoxy-quinazoline with isopropanolic hydrochloric acid in ethanol at 40° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7a53a22a5155489aa5cb48f14fd772db
Source dataset
uspto-grants-2013_03
Patent number
US08399461B2

Reaction notes

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