Hydrochloric Acid → HCID 178486860, compound

HRID 1946944Notes

Reaction equation

HRID 1946944 reaction equation
[Cl:1][C:2]1[C:3]([F:36])=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:34][CH3:35])=[C:16]([O:19][C@H:20]4[CH2:25][CH2:24][C@@H:23]([NH:26]C(OC(C)(C)C)=O)[CH2:22][CH2:21]4)[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[ClH:37]>ClCCl>[ClH:1].[ClH:37].[Cl:1][C:2]1[C:3]([F:36])=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:34][CH3:35])=[C:16]([O:19][C@H:20]4[CH2:21][CH2:22][C@@H:23]([NH2:26])[CH2:24][CH2:25]4)[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486862HCID 178486862, compound

Product 1

HCID 178486860HCID 178486860, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared by treating 843 mg of the compound of Example 3 with 3.3 ml isopropanolic hydrochloric acid (5-6 M) in 8 ml dichloromethane at ambient temperature.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-121d198f133e4080bca58cc4e2444cb4
Source dataset
uspto-grants-2013_03
Patent number
US08399461B2

Reaction notes

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