反应详情

A mixture of 2-butylsulfanyl-3H-pyrimidin-4-one (3.0 g) and phosphorus oxychloride (15 mL) was heated at reflux for 3 h; it was then cooled to RT and evaporated under reduced pressure. The residue was poured into an ice-water mixture, and the resulting mixture was extracted with DCM. The combined organic extracts were washed with a diluted aqueous solution of NaHCO3, dried over Na2SO4, filtered and evaporated under reduced pressure to give 1.2 g of 2-butylsulfanyl-4-chloro-pyrimidine.

1. temperaturewas heated
2. temperatureat reflux for 3 h
3. customevaporated under reduced pressure
4. additionThe residue was poured into an ice-water mixture
5. extractionthe resulting mixture was extracted with DCM
6. washThe combined organic extracts were washed with a diluted aqueous solution of NaHCO3
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customevaporated under reduced pressure