反应详情

A mixture of trans-4-amino-cyclohexanecarboxylic acid (15 g, 83.8 mmol), sulfuric acid (9 mL) and EtOH (400 mL) was stirred at RT overnight. A saturated aqueous solution of NaHCO3 and NaHCO3 (solid) were added until the pH of the mixture reached 7. The solvent was then removed under reduced pressure. Aqueous K2CO3 (50%) was added and the resulting mixture was extracted with EtOAc, the organic extracts dried over Na2SO4, filtered and evaporated under reduced pressure to provide trans-4-amino-cyclohexanecarboxylic acid ethyl ester (12.81 g) as a light yellow oil.

1. customThe solvent was then removed under reduced pressure
2. additionAqueous K2CO3 (50%) was added
3. extractionthe resulting mixture was extracted with EtOAc
4. dry with materialthe organic extracts dried over Na2SO4
5. filtrationfiltered
6. customevaporated under reduced pressure