Hydrogen chloride-ethyl acetate → HCID 66892797, compound

HRID 1947122Notes

Reaction equation

HRID 1947122 reaction equation
[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][N:5]([CH3:33])[C:6]([C:8]1[S:20][C:19]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]([CH2:21][C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:11](=[O:30])[C:10]=2[C:9]=1[O:31][CH3:32])=[O:7].C(OC(=O)C)C.[ClH:41]>C(OCC)(=O)C>[ClH:41].[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][N:5]([CH3:33])[C:6]([C:8]1[S:20][C:19]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]([CH2:21][C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:11](=[O:30])[C:10]=2[C:9]=1[O:31][CH3:32])=[O:7]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57859991HCID 57859991, compound

Product 1

HCID 66892797HCID 66892797, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the N-[2-(dimethylamino)ethyl]-3-methoxy-N-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydrothieno[3,2-c]quinoline-2-carboxamide (180 mg, 0.38 mmol) in ethyl acetate (10 mL) was added 4N hydrogen chloride ethyl acetate solution (0.1 mL), and the obtained precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (144 mg, 55%) as a white powder.

Workup

  1. filtrationthe obtained precipitate was collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-3440cc338d074f18a98ca013a7ced8e7
Source dataset
uspto-grants-2013_03
Patent number
US08399449B2

Reaction notes

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