Hydrogen chloride-ethyl acetate → HCID 66892842, compound

HRID 1947137Notes

Reaction equation

HRID 1947137 reaction equation
[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([NH:28][CH2:29][CH2:30][NH:31][CH:32]([CH3:34])[CH3:33])=[O:27].C(OC(=O)C)C.[ClH:41]>C(OCC)(=O)C>[ClH:41].[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([NH:28][CH2:29][CH2:30][NH:31][CH:32]([CH3:34])[CH3:33])=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57859971HCID 57859971, compound

Product 1

HCID 66892842HCID 66892842, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the compound of Example 97 (150 mg, 0.30 mmol) in ethyl acetate (10 mL) was added 4N hydrogen chloride ethyl acetate solution (0.1 mL), and the resulting precipitate was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (107 mg, 69%) as a white powder.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-32c2babba10c48b5b8445f25ec91dcc7
Source dataset
uspto-grants-2013_03
Patent number
US08399449B2

Reaction notes

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