Sodium Hydroxide → HCID 59829890, compound

HRID 1947176Notes

Reaction equation

HRID 1947176 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[S:36])[NH:15][NH:16][C:17](=O)[C:18]3[CH:23]=[C:22]([CH:24]([CH3:26])[CH3:25])[C:21]([O:27][CH2:28][O:29][CH3:30])=[CH:20][C:19]=3[O:31][CH2:32][O:33][CH3:34])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:24]([C:22]1[C:21]([O:27][CH2:28][O:29][CH3:30])=[CH:20][C:19]([O:31][CH2:32][O:33][CH3:34])=[C:18]([C:17]2[N:13]([C:10]3[CH:11]=[CH:12][C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[CH:8][CH:9]=3)[C:14](=[S:36])[NH:15][N:16]=2)[CH:23]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 59829904HCID 59829904, compound

Product 1

HCID 59829890HCID 59829890, compound

Procedure

Crude crystals of 4-[4-(morpholin-4-yl)-phenyl]-1-(5-isopropyl-2,4-bis-methoxymethoxy-benzoyl)thiosemicarbazide (IM5-S-a01) and 5% aqueous sodium hydroxide (1 mL) were placed in a test tube and refluxed for 2 hours. After completing the reaction, the reaction mixture was extracted with methylene chloride, and the organic layer was combined drying over anhydrous sodium sulfate. Filtration and evaporation gave crude crystals of 5-(5-isopropyl-2,4-bis-methoxymethoxy-phenyl)-4-(4-morpholin-4-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-thione (IM6-S-a01). These crude crystals were subjected to the next reaction without purification in particular.

Workup

  1. temperaturerefluxed for 2 hours
  2. customthe reaction
  3. extractionthe reaction mixture was extracted with methylene chloride
  4. dry with materialthe organic layer was combined drying over anhydrous sodium sulfate
  5. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-61947fe0c73a413eb5ce84d6091b020c
Source dataset
uspto-grants-2013_03
Patent number
US08399464B2

Reaction notes

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