Sodium Hydroxide → HCID 59829890, compound

Participants

Reaction Steps

Crude crystals of 4-[4-(morpholin-4-yl)-phenyl]-1-(5-isopropyl-2,4-bis-methoxymethoxy-benzoyl)thiosemicarbazide (IM5-S-a01) and 5% aqueous sodium hydroxide (1 mL) were placed in a test tube and refluxed for 2 hours. After completing the reaction, the reaction mixture was extracted with methylene chloride, and the organic layer was combined drying over anhydrous sodium sulfate. Filtration and evaporation gave crude crystals of 5-(5-isopropyl-2,4-bis-methoxymethoxy-phenyl)-4-(4-morpholin-4-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-thione (IM6-S-a01). These crude crystals were subjected to the next reaction without purification in particular.

Provenance & Evidence