Lawesson's reagent → HCID 59829845, compound

HRID 1947220Notes

Reaction equation

HRID 1947220 reaction equation
[CH2:1]([O:8][C:9]1[CH:23]=[C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:21]([CH:32]([CH3:34])[CH3:33])=[CH:20][C:10]=1[C:11]([NH:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:44])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:23]=[C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:21]([CH:32]([CH3:34])[CH3:33])=[CH:20][C:10]=1[C:11]([NH:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[S:44])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 59829892HCID 59829892, compound

Product 1

HCID 59829845HCID 59829845, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2,4-bis-benzyloxy-5-isopropyl-N-piperidin-1-yl-benzamide (F67-02: 198 mg, 0.43 mmol), toluene (5 mL) and Lawesson's reagent (157 mg, added in two portions) were placed in a test tube and heated for 2.5 hours under reflux. After the reaction was completed, the reaction mixture was concentrated under reduced pressure. The foam thus obtained was subjected to the next reaction without further purification.

Workup

  1. temperatureheated for 2.5 hours
  2. temperatureunder reflux
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe foam thus obtained
  5. customwas subjected to the next reaction without further purification

Sources & evidence

ORD record
ord-5423066a762d4d15a51708887002c583
Source dataset
uspto-grants-2013_03
Patent number
US08399464B2

Reaction notes

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