Hydrazine hydrate (1:1) → HCID 69273395, compound

HRID 1947221Notes

Reaction equation

HRID 1947221 reaction equation
[CH2:1]([O:8][C:9]1[CH:23]=[C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:21]([CH:32]([CH3:34])[CH3:33])=[CH:20][C:10]=1[C:11]([NH:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=S)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:36][NH2:37]>C(O)C>[CH2:1]([O:8][C:9]1[CH:23]=[C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:21]([CH:32]([CH3:34])[CH3:33])=[CH:20][C:10]=1[C:11](=[N:36][NH2:37])[NH:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59829845HCID 59829845, compound

Product 1

HCID 69273395HCID 69273395, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,4-bis-benzyloxy-5-isopropyl-N-piperidin-1-yl-thiobenzamide (unpurified product of the previous step: F67-03), ethanol (5 mL), hydrazine monohydrate (0.5 mL) was placed in a test tube and heated for 1.5 hours under reflux. After completing the reaction, the reaction mixture was concentrated under reduced pressure while adding toluene several times. The residue thus obtained was subjected to the next step without purification.

Workup

  1. temperatureheated for 1.5 hours
  2. temperatureunder reflux
  3. customthe reaction
  4. concentrationthe reaction mixture was concentrated under reduced pressure
  5. additionwhile adding toluene several times
  6. customThe residue thus obtained
  7. customwas subjected to the next step without purification

Sources & evidence

ORD record
ord-4009514eca384f3c80ce83f8c0466126
Source dataset
uspto-grants-2013_03
Patent number
US08399464B2

Reaction notes

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