反应详情

2.3 g (17.5 mmol) of 4-formylbenzonitrile, 1.98 ml (19.29 mmol) of 2,4-pentanedione, 1 ml (26 mmol) of acetic acid and 0.34 ml (3.5 mmol) of piperidine in 40 ml of anhydrous dichloromethane are stirred under reflux with a water trap for 24 h. After cooling, the reaction solution is washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is recrystallized from diethyl ether. 3.18 g (85% of theory) of the title compound are obtained as a pale brown solid.

1. temperatureunder reflux with a water trap for 24 h
2. temperatureAfter cooling
3. washthe reaction solution is washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution
4. dry with materialThe organic phase is dried over magnesium sulfate
5. concentrationconcentrated
6. customThe residue is recrystallized from diethyl ether