2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 1485603, compound

HRID 1947440Notes

Reaction equation

HRID 1947440 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=O.[CH3:12][O:13][C:14](=[O:22])[C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[N:17][CH:16]=1>O1CCOCC1>[CH3:12][O:13][C:14]([C:15]1[CH:20]=[CH:19][C:18]2[N:17]([CH:2]=[C:3]([C:5]3[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=3)[N:21]=2)[CH:16]=1)=[O:22]

Participants

4

Reactant 2

HCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 737487Methyl 6-aminonicotinate

Product 1

HCID 1485603HCID 1485603, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Bromo-1-(4-fluoro-phenyl)-ethanone (1.135 g, 5.23 mmol) and 6-amino-nicotinic acid methyl ester (795.7 mg, 5.23 mmol) were heated under reflux in 50 ml dioxane for 8.5 hours. After cooling the solid was filtered and dried. Yield: 1.36 g, 96%. MS (mass spectrum): M+H+=271.06.

Workup

  1. temperatureAfter cooling the solid
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-5028b07c723d46b8bf235368a93b0d69
Source dataset
uspto-grants-2013_03
Patent number
US08399476B2

Reaction notes

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