HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 1485603, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Reactant | Methyl 6-aminonicotinate | HCID 737487 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 1485603 | HCID 1485603 | — |
Reaction Steps
2-Bromo-1-(4-fluoro-phenyl)-ethanone (1.135 g, 5.23 mmol) and 6-amino-nicotinic acid methyl ester (795.7 mg, 5.23 mmol) were heated under reflux in 50 ml dioxane for 8.5 hours. After cooling the solid was filtered and dried. Yield: 1.36 g, 96%. MS (mass spectrum): M+H+=271.06.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399476B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5028b07c723d46b8bf235368a93b0d69 |
| Source note | uspto-grants-2013_03 |