反应详情

温度

50 °C

The tert-butyl 1′-(6-chloropyrimidin-4-yl)-4,4′-bipiperidine-1-carboxylate (19 mg, 0.05 mmol) was added to methyl amine in MeOH (1N, 2 mL) in a sealed bottle and heated to 50° C. for 2 days. The reaction crude were cooled down to r.t. and concentrated on rotavapor. The crude mixture was purified by preparative TLC with 10% methanol: dichloromethane to yield title compound.

1. customThe reaction crude
2. temperaturewere cooled down to r.t.
3. concentrationconcentrated on rotavapor
4. customThe crude mixture was purified by preparative TLC with 10% methanol