HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68501189, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 6-Amino-7-bromo-2,3-dihydro-1H-inden-1-one | HCID 53422064 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68501189 | HCID 68501189 | — |
Reaction Steps
A solution of 6-amino-7-bromoindanone (2.4 g, 10.6 mmol) in tetrahydrofuran (150 ml) is treated with sodium borohydride (360 mg, 10.6 mmol) in portions, stirred for two hours, and treated dropwise with water. Tetrahydrofuran is evaporated and the residue is dissolved in ethyl acetate and washed with water. The separated organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-7-bromoindan-1-ol; GC/MS: 228/230 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399490B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a1c06b74b55b406b8107489264cbc82f |
| Source note | uspto-grants-2013_03 |