反应详情

A solution of 6-amino-7-bromoindanone (2.4 g, 10.6 mmol) in tetrahydrofuran (150 ml) is treated with sodium borohydride (360 mg, 10.6 mmol) in portions, stirred for two hours, and treated dropwise with water. Tetrahydrofuran is evaporated and the residue is dissolved in ethyl acetate and washed with water. The separated organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-7-bromoindan-1-ol; GC/MS: 228/230 (M+1)+.

1. customTetrahydrofuran is evaporated
2. dissolutionthe residue is dissolved in ethyl acetate
3. washwashed with water
4. dry with materialThe separated organic layer is dried over sodium sulfate
5. filtrationfiltered
6. customevaporated