反应详情

温度

120 °C

A solution of the above 6-amino-5-chloro-7-cyanoindan-1-ol in isopropanol (20 ml) is treated with aqueous sodium hydroxide (380 mg in 1 ml of water) and heated at 120° C. for 15 hours. Solvent is evaporated, the residue is treated with water and washed with ethyl acetate. The aqueous layer is acidified and extracted with ethyl acetate. The separated organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-5-chloro-7-carboxy-indan-1-ol which is directly used in the next step. LC/MS: 228/230 (M+1)+.

1. customSolvent is evaporated
2. additionthe residue is treated with water
3. washwashed with ethyl acetate
4. extractionextracted with ethyl acetate
5. dry with materialThe separated organic layer is dried over sodium sulfate
6. filtrationfiltered
7. customevaporated