Diethyl(4-nitrophenyl)phosphonate → P-(4-Nitrophenyl)phosphonic acid

HRID 1947793Notes

Reaction equation

HRID 1947793 reaction equation
C([O:3][P:4]([C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)(=[O:8])[O:5]CC)C>Cl>[N+:15]([C:12]1[CH:11]=[CH:10][C:9]([P:4](=[O:3])([OH:5])[OH:8])=[CH:14][CH:13]=1)([O-:17])=[O:16]

Participants

3

Reactant 1

HCID 284865Diethyl(4-nitrophenyl)phosphonate

Product 1

HCID 196997P-(4-Nitrophenyl)phosphonic acidYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of diethyl(4-nitrophenyl)phosphonate (60 g, 230 mmol) in 250 mL of concentrated HCl (aq) was stirred at reflux overnight. The excess HCl was removed under reduced pressure and the product used in further chemistries without purification (46.8 g, yield: 100%).

Workup

  1. temperatureat reflux overnight
  2. customThe excess HCl was removed under reduced pressure
  3. customthe product used in further chemistries without purification (46.8 g, yield: 100%)

Sources & evidence

ORD record
ord-3b0357372e794db29131a38f1aeb1aa9
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

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