Triethyl phosphite → Diethyl(4-amino-3-methoxybenzyl)phosphonate

HRID 1947801Notes

Reaction equation

HRID 1947801 reaction equation
C(P(C[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[C:10]([O:15][CH3:16])[CH:9]=1)(=O)[O-])C.[CH2:17]([O:19][P:20]([O:24]CC)[O:21][CH2:22][CH3:23])[CH3:18]>>[CH2:17]([O:19][P:20]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[C:10]([O:15][CH3:16])[CH:9]=1)(=[O:24])[O:21][CH2:22][CH3:23])[CH3:18]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 86653998Ethyl(4-amino-3-methoxybenzyl)methylphosphinate

Product 1

HCID 86653997Diethyl(4-amino-3-methoxybenzyl)phosphonate

Procedure

This material was prepared according to the procedure described above for ethyl(4-amino-3-methoxybenzyl)methylphosphinate using triethylphosphite in the first step. MS (ES+): m/z 274.01 [MH+] (ZQ3, polar 5 min).

Workup

  1. customThis material was prepared
  2. customm/z 274.01 [MH+] (ZQ3, polar 5 min)

Sources & evidence

ORD record
ord-15752ec06e8c444891901f37631ed3e4
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

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