Hydrochloric Acid → HCID 49822344, compound

HRID 1947821Notes

Reaction equation

HRID 1947821 reaction equation
C([O:3][P:4]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[N:21]=[C:20]([NH:22][CH2:23][C:24]3[C:25]([N:30]([CH3:35])[S:31]([CH3:34])(=[O:33])=[O:32])=[N:26][CH:27]=[CH:28][CH:29]=3)[C:19]([C:36]([F:39])([F:38])[F:37])=[CH:18][N:17]=2)=[CH:11][CH:10]=1)(=[O:8])[O:5]CC)C.Cl>>[CH3:35][N:30]([S:31]([CH3:34])(=[O:33])=[O:32])[C:25]1[C:24]([CH2:23][NH:22][C:20]2[C:19]([C:36]([F:39])([F:37])[F:38])=[CH:18][N:17]=[C:16]([NH:15][C:12]3[CH:11]=[CH:10][C:9]([P:4](=[O:3])([OH:5])[OH:8])=[CH:14][CH:13]=3)[N:21]=2)=[CH:29][CH:28]=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 49822264HCID 49822264, compound

Product 1

HCID 49822344HCID 49822344, compound

Procedure

Also prepared by heating diethyl[4-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]phosphonate (Example 2) at 100° C. with an excess of concentrated hydrochloric acid for 6 h. The reaction mixture was concentrated in vacuo and the residue purified by preparative HPLC (MDP) afford the title compound.

Workup

  1. customAlso prepared
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue purified by preparative HPLC (MDP)

Sources & evidence

ORD record
ord-79570d91efc34a3ab6ee5e117880f2e6
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

Loading…