Trifluoroacetic acid → HCID 67254982, compound

HRID 1947866Notes

Reaction equation

HRID 1947866 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:13]2[C:9]=1[C:10](=[O:24])[N:11]([CH3:23])[CH2:12]2)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C:8]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]2[CH2:19][CH2:20][CH2:21][CH2:22]2)=[C:13]2[C:9]=1[C:10](=[O:24])[N:11]([CH3:23])[CH2:12]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86654009HCID 86654009, compound2×

Product 1

HCID 67254982HCID 67254982, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl[2-methyl-3-oxo-7-(pyrrolidin-1-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate (Compound 109B) was added DCM (0.5 mL) and TFA (0.5 mL, 6 mmol). The solution was stirred at room temperature for 20 minutes. The crude product was dried in vacuo and used directly in next step without further purification. MS (ES+): m/z 246.31 (100) [MH+]; HPLC: tR=0.29 min (UPLC, Analytical).

Workup

  1. dry with materialThe crude product was dried in vacuo
  2. customused directly in next step without further purification

Sources & evidence

ORD record
ord-db2a68cab5ae4c32a38e8e48e478b3b3
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

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