HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-methyl-5-nitroquinolin-4(1H)-one → 5-amino-3-methylquinolin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-methyl-5-nitroquinolin-4(1H)-one | HCID 10512369 | — |
| Reactant | 2-Amino-5-fluoro-N-methylbenzamide | HCID 43132558 | — |
| Product | 5-amino-3-methylquinolin-4(1H)-one | HCID 67254065 | — |
Reaction Steps
The title compound was prepared according to procedure for 2-Amino-5-fluoro-N-methylbenzamide (Compound 102A) using 3-methyl-5-nitroquinolin-4(1H)-one (Eur J Med Chem. 1992, 37, 547-570). 1H NMR (DMSO-d6, 400 MHz): δ=1.87 (d, J=0.76 Hz, 3H), 6.21 (dd, J=7.83, 1.01 Hz, 1H), 6.40 (dd, J=8.08, 1.01 Hz, 1H), 7.12 (t, J=8.08 Hz, 1H), 7.62 (dd, J=5.94, 0.88 Hz, 1H), 11.19 (d, J=5.05 Hz, 1H). MS (ES+): m/z 175.07 [MH+] (TOF, polar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-21de7bc858ae45e69517051092834130 |
| Source note | uspto-grants-2013_03 |