HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetylpiperazine → 4-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-7-amino-2-methyl-2,3-dihydro-1H-isoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetylpiperazine | HCID 83795 | — |
| Reactant | 7-amino-4-[4-(dimethylamino)cyclohexyl]-2-methyl-2,3-dihydro-1H-isoindol-1-one | HCID 67254285 | — |
| Reactant | 7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-one | HCID 67256125 | — |
| Product | 4-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-7-amino-2-methyl-2,3-dihydro-1H-isoindol-1-one | HCID 67256455 | — |
Reaction Steps
The title product was prepared according to the procedure for Compound 233A using 7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-one and 1-acetylpiperazine. 1H NMR (CDCl3, 400 MHz): δ=1.80-1.98 (m, 3H), 2.01-2.14 (m, 6H), 2.25 (d, J=19.20 Hz, 1H), 2.42-2.62 (m, 5H), 3.12-3.17 (m, 3H), 3.45-3.70 (m, 4H), 4.28-4.33 (m, 2H), 5.10 (br. s., 2H), 6.58 (d, J=8.08 Hz, 1H), 7.17 (d, J=8.34 Hz, 1H). MS (ES+): m/z 371.26 [MH+] (TOF, polar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-67cc9a46fd2145a9af502e9200a789d3 |
| Source note | uspto-grants-2013_03 |