Hydrochloric Acid → HCID 44537952, compound

Participants

Reaction Steps

A solution of 1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(tetrahydropyran-4-yl)-cyclohexyl]propylamine (8, 83 mg, 0.16 mmol) in 2-propanol (1 mL) was treated with 2N aqueous hydrochloric acid (0.5 mL) and stirred at room temperature until complete conversion was observed. The reaction mixture was evaporated and lyophilized from water twice to give 68 mg of the title compound (Example 1) as its hydrochloride. Rt 2.40 min (Method A). Detected mass: 419.4 (M+H+).

Provenance & Evidence