反应详情

A solution of 1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-(tetrahydropyran-4-yl)-cyclohexyl]propylamine (8, 83 mg, 0.16 mmol) in 2-propanol (1 mL) was treated with 2N aqueous hydrochloric acid (0.5 mL) and stirred at room temperature until complete conversion was observed. The reaction mixture was evaporated and lyophilized from water twice to give 68 mg of the title compound (Example 1) as its hydrochloride. Rt 2.40 min (Method A). Detected mass: 419.4 (M+H+).

1. customThe reaction mixture was evaporated