(4-Methoxyphenyl)boronic acid → HCID 54762487, compound

HRID 1948242Notes

Reaction equation

HRID 1948242 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[CH3:9][O:8][C:5]1[CH:4]=[CH:3][C:2]([C:15]2[CH:16]=[CH:17][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 27348955-Bromo-2-methoxypyridine

Product 1

HCID 54762487HCID 54762487, compoundYield 61.4%

Procedure

According to Scheme 4 Method B: The title compound was prepared according to Example 1 Step 3 from 5-bromo-2-methoxypyridine (12.1 mmol, 2.30 g) and 4-methoxyphenylboronic acid (18.2 mmol, 2.76 g), then purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2, CH2Cl2/MeOH 100/0 to 95/5), yielding the title compound (1.60 g, 61%).

Workup

  1. customThe title compound was prepared
  2. custompurified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2, CH2Cl2/MeOH 100/0 to 95/5)

Sources & evidence

ORD record
ord-56e1f2c42d5a40dbb78e0ab39621d4d9
Source dataset
uspto-grants-2013_03
Patent number
US08399493B2

Reaction notes

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