HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,4-Dichloro-5-methyl-1H-pyrrole-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 2-((3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl)-1,3-thiazole-5-carboxylate | HCID 68517797 | — |
| Product | 3,4-Dichloro-5-methyl-1H-pyrrole-2-carbonyl chloride | HCID 86038394 | — |
Reaction Steps
A solution of 10.4 g (54 mmol) of 3,4-Dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 1) in 100 ml SOCl2 was heated at reflux for 30 min. Solvent was removed to afford product. NMR (CDCl3): 2.3 (s, 1H), 8.8 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399489B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-aa3355fd84c54e2cbb66491abc09bce1 |
| Source note | uspto-grants-2013_03 |