Methyl iodide → tert-butyl N-[(2S)-2-methoxypropyl]carbamate

HRID 1948389Notes

Reaction equation

[CH3:1][O:2][C@H:3]([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].O[C@@H](C)CNC(=O)OC(C)(C)C.CI>>[CH3:1][O:2][C@@H:3]([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:10])([CH3:9])[CH3:11]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 11789722N-Boc-(S)-1-amino-2-propanol

HCID 86641515tert-butyl [(2R)-2-methoxypropyl]carbamate

Product 1

HCID 86643351tert-butyl N-[(2S)-2-methoxypropyl]carbamate

Procedure

The title compound was synthesized by using the method analogous to the synthesis of Intermediate 277 starting with tert-butyl [(2S)-2-hydroxypropyl]carbamate and alkylating it with methyl iodide.

Sources & evidence

ORD record: ord-983f2c69132347da8ca99934c476e524
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399489B2

Reaction notes

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