反应详情

温度

0 °C

5-[2-(acetylamino)-4-methyl-1,3-thiazol-5-yl]thiophene-2-sulfonyl chloride, prepared as in Step II of Example 1 (500 mg; 1.48 mmol; 1.00 eq) in DCM (30 ml). The solution is degassed with N2 and cooled down to 0° C. Triethylamine (1.0 ml; 7.42 mmol; 5.00 eq) followed by N,N-dimethyl-N′-ethylethylenediamine (1.2 ml; 7.42 mmol; 5.00 eq) are added. After 30 minutes at 0° C., the reaction is complete. The reaction mixture is washed with NaHCO3 sat. (twice) and water (twice). The organic phase is dried over MgSO4, filtered and concentrated under vacuum, affording Compound (22) as a beige solid (544 mg; 88%).

1. customThe solution is degassed with N2
2. additionare added
3. washThe reaction mixture is washed with NaHCO3 sat. (twice) and water (twice)
4. dry with materialThe organic phase is dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated under vacuum