Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 68845325 | HCID 68845325 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 12595535 | HCID 12595535 | — |
Reaction Steps
Conc. HCl (60 ml) was added to ethyl 5-cyano-2-oxo-5-(thiophen-2-yl)cyclohexanecarboxylate (12 g) in acetic acid (120 ml). The reaction mixture was refluxed for 3 hours (110° C.-120° C.). The mixture was cooled to 0° C. and adjusted with 2N NaOH-solution (200 ml) until it was neutral (pH ˜7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399503B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-2371d574b98c495baf6f686b9c315de5 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
