Hydrochloric Acid → HCID 12595535, compound

HRID 1948594Notes

Reaction equation

HRID 1948594 reaction equation
Cl.[C:2]([C:4]1([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][CH:8](C(OCC)=O)[C:7](=[O:15])[CH2:6][CH2:5]1)#[N:3].[OH-].[Na+]>C(O)(=O)C>[C:2]([C:4]1([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][CH2:8][C:7](=[O:15])[CH2:6][CH2:5]1)#[N:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68845325HCID 68845325, compound

Product 1

HCID 12595535HCID 12595535, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

Conc. HCl (60 ml) was added to ethyl 5-cyano-2-oxo-5-(thiophen-2-yl)cyclohexanecarboxylate (12 g) in acetic acid (120 ml). The reaction mixture was refluxed for 3 hours (110° C.-120° C.). The mixture was cooled to 0° C. and adjusted with 2N NaOH-solution (200 ml) until it was neutral (pH ˜7).

Workup

  1. temperatureThe reaction mixture was refluxed for 3 hours (110° C.-120° C.)

Sources & evidence

ORD record
ord-2371d574b98c495baf6f686b9c315de5
Source dataset
uspto-grants-2013_03
Patent number
US08399503B2

Reaction notes

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