Hydrochloric Acid → HCID 68842647, compound

Participants

Reaction Steps

6 M hydrochloric acid (5 ml) was added to a solution of 4-(8-benzyl-1,4-dioxaspiro[4.5]dec-8-yl)morpholine (1.00 g, 3.15 mmole) in acetone (5 ml). After 24 hours further 6 M hydrochloric acid (2.5 ml) was added to the reaction solution, which was stirred for a further 3 days at room temperature, following which it was made alkaline (pH ˜9) with 25% potassium carbonate solution and extracted with diethyl ether (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated by evaporation in vacuo.

Provenance & Evidence