Hydrochloric Acid → HCID 68842647, compound

HRID 1948611Notes

Reaction equation

HRID 1948611 reaction equation
Cl.[CH2:2]([C:9]1([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH2:18][CH2:17][C:12]2(OCC[O:13]2)[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:2]([C:9]1([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH2:18][CH2:17][C:12](=[O:13])[CH2:11][CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 11430Potassium CarbonateHCID 68841521HCID 68841521, compound

Product 1

HCID 68842647HCID 68842647, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6 M hydrochloric acid (5 ml) was added to a solution of 4-(8-benzyl-1,4-dioxaspiro[4.5]dec-8-yl)morpholine (1.00 g, 3.15 mmole) in acetone (5 ml). After 24 hours further 6 M hydrochloric acid (2.5 ml) was added to the reaction solution, which was stirred for a further 3 days at room temperature, following which it was made alkaline (pH ˜9) with 25% potassium carbonate solution and extracted with diethyl ether (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated by evaporation in vacuo.

Workup

  1. extractionextracted with diethyl ether (3×20 ml)
  2. dry with materialThe combined organic phases were dried with sodium sulfate
  3. concentrationconcentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-45235116522a43fdb5e849d0ee03133e
Source dataset
uspto-grants-2013_03
Patent number
US08399503B2

Reaction notes

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