反应详情

[8-(3-methoxypropyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethylamine (8.11 g, 31.5 mmole) was dissolved in water (12 ml), conc. HCl (19.5 ml) was added while cooling with ice, and the reaction mixture was stirred for 3 days at room temperature. The reaction mixture was washed with ether (2×75 ml). The solution was then made alkaline with 5N NaOH and extracted with dichloromethane (3×75 ml). The combined organic phases were washed with water (75 ml), dried over Na2SO4, filtered, and the solvent was removed in vacuo.

1. temperaturewhile cooling with ice
2. washThe reaction mixture was washed with ether (2×75 ml)
3. extractionextracted with dichloromethane (3×75 ml)
4. washThe combined organic phases were washed with water (75 ml)
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe solvent was removed in vacuo