Hydrochloric Acid → HCID 57475115, compound

Participants

Reaction Steps

Firstly 1,4-dioxaspiro[4,5]decan-8-one (4.84 g, 31 mmole) followed by potassium cyanide (4.85 g, 74.4 mmole) in water (15 ml) were added while cooling with ice to a mixture of 4 N hydrochloric acid (8.1 ml), methanol (4.9 ml) and azetidine (8.5 g, 10 ml, 149 mmole). The mixture was stirred for 5 days at room temperature, water (50 ml) was then added, and the mixture was extracted with diethyl ether (3×50 ml). The combined organic phases were dried with sodium sulfate and concentrated by evaporation in vacuo.

Provenance & Evidence