Triethylamine → HCID 59450542, compound

HRID 1948666Notes

Reaction equation

HRID 1948666 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]1[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17].C(N(CC)CC)C.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>ClCCl>[CH3:25][S:26]([O:9][CH2:8][C:7]1[C:2]([CH3:1])=[C:3]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:17])[CH:4]=[CH:5][CH:6]=1)(=[O:28])=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 23083060HCID 23083060, compound

Product 1

HCID 59450542HCID 59450542, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product from Step C (1 g, 4.42 mmole) in dichloromethane (10 mL) was added triethylamine (0.54 g, 5.3 mmol) followed by methanesulfonyl chloride (0.6 g, 5.3 mmol) dropwise. The mixture was stirred at room temperature for 3-4 h. It was then washed with water and brine, and dried over magnesium sulfate, and concentrated to dryness to give the title compound as a colorless oil.

Workup

  1. washIt was then washed with water and brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-cb4a676048a84c26b13da07930c7eb14
Source dataset
uspto-grants-2013_03
Patent number
US08399507B2

Reaction notes

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