反应详情

Trimethylsilyldiazomethane solution (2 M in Hexane) (18 mL, 35 mmol) was added dropwise to a stirred solution of the product of Step A (7.3 g, 33.2 mmol) in benzene containing 20% of methanol (total: 100 mL) at room temperature until solution retained a yellow color. The mixture was concentrated to remove the organic solvent. The remaining oil was poured over a silica gel plug in a 60-mL filter frit funnel and eluting with 200 mL of hexane containing 10% ethyl acetate. The filtrate was then concentrated to dryness to give the title compound as a bright yellow oil.

1. concentrationThe mixture was concentrated
2. customto remove the organic solvent
3. additionThe remaining oil was poured over a silica gel plug in a 60-mL
4. filtrationfilter frit funnel
5. washeluting with 200 mL of hexane containing 10% ethyl acetate
6. concentrationThe filtrate was then concentrated to dryness