Potassium Cation → 3-chloro-2,4-difluoro-N-(2-hydroxyethyl)-N-methylbenzamide

HRID 194867Notes

Reaction equation

HRID 194867 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH2:8][N:9]([C:10]([c:11]1[c:12]([F:19])[c:13]([Cl:18])[c:14]([F:17])[cH:15][cH:16]1)=[O:20])[CH3:21])([CH3:5])([CH3:22])[CH3:23].[C:55](=[O:56])([O-:57])[O-:58].[CH3:62][C:63]([N:64]([CH3:65])[CH3:66])=[O:67].[K+:59].[K+:60].[OH2:61].[OH:24][c:25]1[cH:26][c:27]([C:46]([NH:47][c:48]2[cH:49][cH:50][n:51]([CH3:52])[n:53]2)=[O:54])[cH:28][c:29]([O:30][CH:31]([CH3:32])[CH2:33][O:34][Si:35]([CH:36]([CH3:37])[CH3:38])([CH:39]([CH3:40])[CH3:41])[CH:42]([CH3:43])[CH3:44])[cH:45]1>>[OH:6][CH2:7][CH2:8][N:9]([C:10]([c:11]1[c:12]([F:19])[c:13]([Cl:18])[c:14]([F:17])[cH:15][cH:16]1)=[O:20])[CH3:21]

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 31374DimethylacetamideHCID 57663164N-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3-chloro-2,4-difluoro-N-methylbenzamideHCID 671572533-hydroxy-N-(1-methylpyrazol-3-yl)-5-[1-tri(propan-2-yl)silyloxypropan-2-yloxy]benzamide

Product 1

HCID 576632133-chloro-2,4-difluoro-N-(2-hydroxyethyl)-N-methylbenzamide

Sources & evidence

ORD record
ord-0a54428bce4d4ff79b254a104e9ec6e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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