2-Chlorothiazole-5-carbonitrile → (1-Carbamoyl-4-adamantyl) 3-(5-cyanothiazol-2-ylamino)pyrrolidine-1-carboxylate

Participants

Reaction Steps

The title compound was prepared from (3R) (1-carbamoyl-4-adamantyl) 3-(tert-butoxycarbonylamino)pyrrolidine-1-carboxylate isomer 2 following procedures analogous to those described in Example 33 using 2-chloro-5-cyanothiazole in Step 2. LC-MS Method 1 tR=1.32 min, m/z=415; 1H NMR (CD3OD) 1.55 (2H), 1.85-2.15 (12H), 2.25 (m, 1H), 3.35-3.80 (4H), 4.40 (br s, 1H), 4.78 (s, 1H), 7.74 (s, 1H).

Provenance & Evidence