反应详情

Compound No. 12 was prepared according to a process similar to that described in stage 8.4, by reacting 0.15 g (0.28 mmol) of N-[6-(azetidin-1-yl)pyridin-3-yl]-5-iodo-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide, prepared according to the protocol described in stage 8.3, with 167 mg (0.84 mmol) of diphenylmethylsilane in the presence of 0.18 g (0.84 mmol) of potassium triphosphate and of 15 mg (0.03 mmol) of bis(tri-tert-butylphosphine)palladium in 2 ml of dry 1-methyl-2-pyrrolidinone (NMP). 19 mg of the expected product are obtained.

1. custom12 was prepared
2. customprepared